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 Pierce Butler, a former Marine and long-retired marijuana smuggler, whose wife is suffering from a rare type of cancer, must return to his drug-running ways and make one Final Load in order to save his house, his company, and his wife.

　　繁华的国际大都会香港闹市中心，口若悬河的洪家宝（陈百祥 饰）带着傻乎乎的小弟麦交（邵国华 饰）公然行窃，结果路上遭遇妙龄女郎嘉嘉（张艾嘉 饰）举报。虽然两人百般抵赖，但在最后关头漏了马脚，被警察关进监狱。令洪、麦意想不到的是，嘉嘉居然是监狱的辅导官，所谓冤家路窄，洪家宝真是窝了一肚子火。二人所在的牢房狱霸横行，为了逃出对方魔爪，他们不惜羞辱监狱长官。经过一段时间牢狱之灾，二人和狱中认识的伙伴冠仁（胡大为 饰）出狱。谁知他们死性不改，骗吃骗喝再度锒铛入狱，这次又撞上了有着一副好皮囊、爱装警察的小混混荣仔（张国荣 饰）。　　洪家宝大骂荣仔，意想不到的是荣仔的老姐居然就是洪的仇敌嘉嘉……

　　创意鬼才亨利·塞利克和制片人乔丹·皮尔这次带来动画《恶魔兄弟》，讲述了狡猾的恶魔兄弟温德尔（科甘-迈克尔·凯配音）和瓦尔德（皮尔配音）向凯特·艾略特（一名被负罪感支配的坚强少女）求助，希望她能将他们召唤至人间。但与之相对的，凯特也提出要求，进而引发了一场奇异无比、笑料百出的独特冒险。影片全篇采用定格动画的手工艺术进行制作，是一部无视生死法则的动画狂想曲。

 The story follows a nameless murderer, wearing a nightmarish mask, randomly murdering people across the U.S. in an attempt to secure his passage to hell. A patrolman’s pregnant wife, a fellow police officer, witnesses the killer murdering her husband and seeks to bring his to justice